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, Salomé Riess Laboratoire Toxlab , 7 rue Jacques Cartier, Paris 75018, France *Correspondence to: Laboratoire Toxlab, 7 rue Jacques Cartier, Paris 75018, France. Email: salome.riess@labotoxlab.com Search for other works by this author on: Oxford Academic Marjorie Chèze Laboratoire Toxlab , 7 rue Jacques Cartier, Paris 75018, France Search for other works by this author on: Oxford Academic Aurelie Muckensturm Laboratoire Toxlab , 7 rue Jacques Cartier, Paris 75018, France Search for other works by this author on: Oxford Academic Nadine Klinger Laboratoire ChemTox , 3 Rue Gruninger, Illkirch-Graffenstaden 67400, France Search for other works by this author on: Oxford Academic Olivier Roussel Laboratoire ChemTox , 3 Rue Gruninger, Illkirch-Graffenstaden 67400, France Search for other works by this author on: Oxford Academic Vincent Cirimele Laboratoire Toxlab , 7 rue Jacques Cartier, Paris 75018, France Laboratoire ChemTox , 3 Rue Gruninger, Illkirch-Graffenstaden 67400, France Search for other works by this author on: Oxford Academic
https://orcid.org/0009-0003-0975-9785 Journal of Analytical Toxicology, bkae021, https://doi.org/10.1093/jat/bkae021
Published:
29 March 2024
Article history
Received:
11 October 2023
Revision received:
23 February 2024
Editorial decision:
26 February 2024
Accepted:
19 March 2024
Published:
29 March 2024
Corrected and typeset:
15 April 2024
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Salomé Riess, Marjorie Chèze, Aurelie Muckensturm, Nadine Klinger, Olivier Roussel, Vincent Cirimele, 2-Fluorodeschloroketamine consumption: About two deaths and a case of self-mutilation, Journal of Analytical Toxicology, 2024;, bkae021, https://doi.org/10.1093/jat/bkae021
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Abstract
2-Fluorodeschloroketamine (2-FDCK) is a new psychoactive substance (NPS), close to the ketamine structure. Few cases of 2-FDCK intake are described in the forensic literature, especially concerning death cases. We report here a case of self-mutilation (Case 1) and two forensic deaths linked to 2-FDCK consumption. The second case involved a man found dead in the street, having been stabbed. The third case was a man found dead following a suspected overdose and in an advanced state of putrefaction. For all three cases, biological fluids such as blood and urine were analyzed, as was hair for the two fatal cases. The aim of this study was to identify and quantify 2-FDCK and its main metabolites in different matrices. Biological fluids and hair were analyzed by liquid chromatography coupled with tandem mass spectrometry after decontamination and extraction. Seized products were analyzed by gas chromatography–mass spectrometry and assayed, when possible, by ultra-performance liquid chromatography with diode-array detection. 2-FDCK was detected and quantified in the peripheral blood of Cases 1, 2 and 3 (457, 758 and 5885 µg/L, respectively), as were its main metabolites nor-2-FDCK, dihydro-nor-2-FDCK and dihydro-2-FDCK. In the 1 cm long hair of Cases 2 and 3, 2-FDCK was also detected (approximately 4149 and 79824 pg/mg, respectively). Deschloroketamine (DCK) was found in the biological fluids of Cases 1, 2 and 3 (10, 8 and 350 µg/L, respectively), as well as in hair of Cases 2 and 3 (65 and around 8119 pg/mg, respectively). In Case 3, as a small bag containing DCK powder was seized from his home, we can assume that DCK was taken. On the contrary, to our knowledge, it has not been established that Case 2 took DCK alone, so we can assume that it may be the first case to report DCK from 2-FDCK metabolism in fluids as well as in hair.
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